RAF Typhoon FGR4s have conducted a mission with France's air force in a combined operation against an underground arms cache in Syrian territory used by the IS group, per a report from the UK Ministry of Defence.
The location, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was positioned in mountains just above Palmyra in the heart of Syria.
"The RAF jets utilized Paveway IV guided bombs to strike a several approach shafts down to the depot... early reports indicate the objective was successfully hit," officials stated.
There was no sign of any civilian casualties in the operation conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
IS - alternatively referred to as Daesh - imposed militant control over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This action shows our UK leadership, and determination to operate in unison with our allies, to eliminate any resurgence of Daesh and their violent and radical beliefs in the area," UK Defence Secretary John Healey remarked.
British military aircraft have conducted patrols over Syrian airspace to "deter any efforts to regroup" of the group after its military defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of our armed forces who took part in this strike for their expertise and their valour," the Defence Secretary commented. "They were part of thousands of British troops on duty over the holidays. This operation, to eliminate militants who threaten our security, highlights how UK forces are prepared to act, continuously, protecting the UK at home and influential overseas."
Last December, the American forces carried out what it called a "massive strike" against IS targets in Syria, after an assault resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The United Nations estimates IS still boasts an estimated 5,000 to 7,000 fighters in Iraq and Syria.